beauty & technology•Tue, October 20, 2026•5 min read

Why CHANDO Group’s New 'Fatigue-Aging' Discovery Is Changing Skincare

CHANDO Group has introduced a breakthrough paradigm in cosmetic science focused on 'Fatigue-Aging.' By utilizing AI to identify a powerful new peptide, the company is addressing how modern stress and exhaustion accelerate skin aging.

A New Paradigm in Skin Health

At the 12th edition of COSMETIC 360 in Paris, CHANDO Group took the main stage at the Louvre to challenge how we think about anti-aging. The company debuted 'Fatigue-Aging' (or 'Fatiguescence')—a research-backed concept that suggests our fast-paced, high-stress lifestyles are physically manifesting on our skin earlier than ever before.

Collaborating with the Shanghai Institute of Nutrition and Health, CHANDO discovered that the onset of wrinkle formation for Chinese women has shifted roughly four years earlier compared to data from 2018. The culprit? A combination of cumulative stress, sleep deprivation, and lifestyle factors that impact cellular energy metabolism.

CHANDO Group presenting its latest research findings at the 2026 COSMETIC 360 summit in Paris.

AI-Driven Ingredient Innovation

To combat these fatigue-related aging symptoms, CHANDO Group turned to computational biology. By screening a database of over 2.8 million yeast protein sequences, researchers identified the HiMurchaSin™ Super Anti-Aging Peptide, derived from Himalayan extremophile yeast.

Targets PGC-1α, a key regulator of mitochondrial energy metabolism.
Delivers 8.5 times the penetration capacity of conventional tetrapeptides.
Promotes cellular renewal and combats fatigue-induced skin degradation.
Recognized with the 2026 INPD Raw Materials Award.

The Future of Anti-Aging Science

This research signifies a shift from traditional cosmetic chemistry toward 'Scientific Beauty.' Shanshan Jiang, MD, emphasized during her keynote that addressing chronic stress aging is now a central paradigm for Chinese skin research. By focusing on mitochondrial biogenesis—the process by which cells increase their energy output—CHANDO is moving beyond surface-level treatments to address skin health at the cellular level.

By targeting PGC-1α, a key regulator of mitochondrial energy metabolism, [the peptide] helps support cellular energy production and address fatigue-related skin aging at the cellular level.
— CHANDO Group Research Team

Key Takeaways

CHANDO Group introduced 'Fatigue-Aging' at COSMETIC 360, highlighting how lifestyle stress accelerates skin aging.
Data indicates wrinkle formation is beginning approximately four years earlier than it did in 2018.
The award-winning HiMurchaSin™ peptide was discovered using AI to analyze 2.8 million protein sequences.
The new peptide significantly outperforms conventional tetrapeptides with 8.5x greater skin penetration.
The research focuses on mitochondrial biogenesis to restore vitality to fatigued skin.

FAQ

What is 'Fatigue-Aging'?

Fatigue-Aging, or 'Fatiguescence,' refers to the acceleration of visible signs of aging—such as wrinkles—caused by chronic lifestyle stress, poor sleep, and reduced mitochondrial energy in skin cells.

How does CHANDO use AI in its research?

CHANDO Group uses AI-driven computational biology to screen millions of protein sequences to identify effective ingredients, such as the award-winning HiMurchaSin™ peptide.

What is the HiMurchaSin™ peptide?

It is a proprietary anti-aging peptide derived from Himalayan extremophile yeast that targets PGC-1α to support cellular energy production and mitochondrial health.

Where can I find products containing this technology?

This technology is featured in the seventh generation of CHANDO's 'Super Anti-Aging Little Purple Bottle' and the reformulated 'Super Anti-Aging Cream'.